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Insulin detemir: A historical perspective on a modern basal insulin analogue

Primary Care Diabetes, pages S31 - S42


Insulin detemir provides prolonged, reproducible blood glucose reduction through a mechanism unique among basal insulins. It was originally studied clinically in predominantly basal + bolus regimens and found to be associated with a low risk of hypoglycaemia compared to insulin NPH, and reduced weight gain compared to other basal insulins. Insulin detemir has been increasingly studied in basal-only insulin regimens in type 2 diabetes, in which an understanding of how to optimize its use has been built incrementally. Glycaemic control and limitation of weight gain tend to be maximized by once-daily (evening) dosing, earlier initiation and careful titration to appropriate fasting glucose targets.

Keywords: Insulin detemir, Basal insulin analogue, Hypoglycemia, Weight gain.


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a University of Miami Miller School of Medicine, Miami, Florida, USA

b Center for Diabetes and Metabolism, Fachklinik, Bad Heilbrunn, Germany

c Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA

* Corresponding author. Luigi Meneghini. Division of Endocrinology & Diabetes, University of Miami School of Medicine, Diabetes Research Institute, 1450 NW 10th Avenue, Miami, Florida 33136, USA. Tel.: +1 305-243-5366; fax: +1 305-243-1200